TOYOPEARL Sulfate-650F

TOYOPEARL Sulfate-650F resin is a strong cation exchange resin that exhibits high salt tolerance.  This resin offers the strongest capture of monoclonal antibody (mAb) aggregates over a wide pH range without losing its binding capacity for mAb. With the use of optimized binding conditions, a dynamic binding capacity of > 120 g/L of mAb can be easily achieved with TOYOPEARL Sulfate-650F. This high binding capacity translates into lower operating costs per gram of antibody produced.

A TOYOPEARL HW-65F polymeric bead has been functionalized with a sulfate (SO^4-) group.  The 100 nm pore size of this resin, along with proprietary bonding technology, makes TOYOPEARL Sulfate-650F ideal for applications performed in physiological conditions or for post-protein A removal of aggregates.