Industry Expert Talks and Interactive Sessions

Innovation in polymeric drug delivery systems sits at the intersection of polymer chemistry, biology, and analytical science. No single discipline or organization can address this complexity alone.

This session brings together experts from academia and industry - Dr Maria Jesus Vicent (CIPF), Dr. Sergio Esteban (Curapath), and Dr Snežana Đorđević (Tosoh Bioscience) to discuss how collaborative approaches to physico chemical characterization can accelerate understanding and innovation in polymer therapeutics.

We will also highlight the importance of detailed characterization and analytical mindset in the development of polymer-based drug delivery systems and how any advancement in science, including the rapidly growing drug delivery field, needs to be followed by the advancement in analytical technology.

Scientific Posters and Presentations

Multi-Angle Light Scattering (MALS) coupled with separation techniques has proven indispensable for characterizing drug delivery systems (DDS). Molecular weight determination, size distribution, aggregation profiling, and structural conformation are necessary for ensuring safety, efficacy, and reproducibility. Current MALS methodologies face limitations in detecting particles smaller than 12/15 nm due to their weak scattering signals and small angular dependence. Therefore, there is a need for more sensitive MALS detectors capable of detecting and analyzing these sub-15 nm components and detect small difference in size that can impact overall behavior and efficacy.

Learning Objectives:

• Understand advantage of MALS detector over column calibration in polymer characterization.
• Understand limits of conventional MALS for sub 15 nm DDS and how improved sensitivity boosts Mw and size accuracy.
• Explain how advanced MALS and viscometry reveal structure–property relationships in polymer-based DDS.

Efficient analytical characterization of adeno associated viruses (AAVs) is critical for process development and quality control but remains time consuming with established methods. Techniques such as analytical ultracentrifugation (AUC) require several hours, while liquid chromatographic approaches including anion exchange chromatography (AEX) size exclusion chromatography coupled to multi angle light scattering (SEC–MALS) typically require ≥30 minutes per analysis and additional time to reach stable operating conditions. Here, we report a high throughput SEC–MALS workflow enabling the simultaneous determination of AAV fill state and titer within 8 minutes per sample.

Learning Objectives:

• Participants will learn that SEC–MALS Can Be Successfully Adapted for High Throughput AAV Analysis.
• Participants will learn that Stationary Phase and Geometry are Primary Drivers for Analysis Speed.

Resources