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Description

CaPure-HA is a hydroxyapatite resin used in the chromatographic separation of biomolecules. Unlike other resins available from Tosoh Bioscience, CaPure-HA is both the ligand and the base bead.

CaPure-HA is specifically developed for the purification of monoclonal and polyclonal antibodies, the separation of antibody isoforms, isozymes, the purification of antibody fragments, and the isolation of single-stranded from double-stranded DNA. CaPure-HA resin has been sintered at high temperatures for increased mechanical and chemical stability, allowing it to withstand the rigors of industrial-scale applications.

CaPure-HA has a demonstrated dynamic binding capacity (DBC), at 10% breakthrough, of greater than 20 g/L for lysozyme at residence times as low as one minute and greater than 30 g/L for human IgG at residence times as low as 2 minutes.

CaPure-HA provides exceptional separation properties and unequalled selectivity and resolution for multiple classes of biomolecules. The highly selective and robust nature of CaPure-HA offers the flexibility to use this resin at any stage in a process from capture to final polishing.

Specifications

Applications
Peptides, Enzymes, mAb fragments, Endotoxins, Aggregates, Proteins, Other recombinant proteins, Lipoproteins, DNA/RNA, Monoclonal antibodies
Resin Volume
50 g, 500 g, 100 g, 250 g, 5 kg, 1 kg
Product Category
Process Media
Process Step
Intermediate Purification
Particle Size (µm)
39
Group
Specialty
Mode
Hydroxyapatite

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