Mixed-Mode or Multimodal Chromatography expands the range of chromatographic modes applied in biopurification. Mixed-Mode media combine ionic and hydrophobic interactions and offer new selectivities and a higher salt tolerance than traditional ion exchange media.
Applications
Mixed-Mode Resins are especially suited for the purification of target molecules that are difficult to purify using common purification platforms. Mixed-mode media can be used for direct processing of clarified feedstocks at physiological salt concentrations as well as for intermediate and polishing applications, such as mAb aggregate removal.
