TOYOPEARL Super A
TOYOPEARL Super A resin provides a cutting-edge experience in protein A media, blending top-tier critical performance attributes with exceptional operational flexibility.
>70 g/L DBC at 5 min RT.
90% of initial DBC after 100 CIP cycles at 0.5 M NaOH or 70 cycles at 1 M NaOH.
Hexameric ligand.
Stable at flowrates up to 600 cm/hr.
High-Capacity, 1 M NaOH-Stable, Protein A Resin for Intensified mAb Capture and Continuous Bioprocessing
Brand: TOYOPEARL
Manufacturers:
Description
TOYOPEARL Super A is Tosoh's most advanced Protein A resin. It is the first choice to screen for mAb and Fc-containing molecules. It is designed for capture chromatography from high titer feedstocks and excels when used for intensified chromatography.
- High DBC at fast flowrates, enables more mass to be processed per unit time.
- Excellent alkaline stability over extended cycling extends the lifespan of the resin and improves bioburden control
- Hexameric C domain, codon-optimized ligand with multipoint covalent attachment prevents ligand loss during CIP
- Rapid mass transfer results in mild elution pool pH, making it well suited for pH sensitive molecules
- Polymethacrylate bead is stable at flowrates up to 600 cm/hr, making it well suited for intensified, continuous chromatography
- Animal origin free
Specifications
| Particle Size (µm) | 45 |
|---|---|
| Pore Size (nm) | 100 |
| Process Step | Capture |
| Resin Volume | 10 mL, 5 L, 1 L, 100 mL, 25 mL, 5 mL |
| Mode | Protein A |
| Applications | Monoclonal antibodies |