Analysis of results of specific IgE in 100 atopic dermatitis patients with the use of multiplex examination ALEX² —Allergy Explorer
Atopic dermatitis (AD) is a common inflammatory skin disease causing redness, and irritation of the skin. Exacerbation of AD through spreads beyond the skin to initiate the atopic march, which includes food allergy, bronchial asthma and allergic rhinitis. Molecular allergy testing, particularly using allergen microarrays, is currently being implemented into daily diagnostic work-up of allergies. The molecular components are recombinant proteins with different IgE binding capacities. ALEX2 - Allergy Explorer is an in-vitro assay for the measurement of allergen-specific IgE antibodies & is intended to aid in the diagnosis of IgE-mediated allergic disorders. The complete dermatological and allergological examination, including the examination of the sensitization to molecular components with ALEX2 was performed.
This study analyses the results of specific IgE to 117 allergenic extracts and 178 molecular components in patients suffering from atopic dermatitis. Patients with severe AD, showed high levels of specific IgE to proteins of the NPC2 family (storage mites), lipocalin (dog), arginine kinase (moulds, cockroach, house dust mite, shrimp), uteroglobin (cat, rabbit), Mn superoxide dismutase (moulds), PR-10 protein (beech, apple, hazelnut), peritrophin-like domain (house dust mite) and rye pollen. In a subgroup of patients with bronchial asthma, high IgE values against molecular components from house dust mites, storage mites, grass pollen and moulds were observed. Thus, it confirmed the significant relationship between the severity of AD, the occurrence of bronchial asthma and allergic rhinitis and high levels of specific IgE to allergen. These results may be important for regime measures and immunotherapy.
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