Sensitization profiles to house dust mite Dermatophagoides pteronyssinus molecular allergens
Allergic diseases are among the most common chronic diseases worldwide and have a major impact on the quality of life on the patients. The prevalence of these diseases has increased worldwide to estimated 20%–30%. Among the various allergenic sources, house dust mites (HDMs) such as Dermatophagoides pteronyssinus (Der p), have emerged as significant trigger for respiratory allergic diseases as well as dermatitis.
Given the global prevalence of HDM allergy and its varying sensitization profiles, this study aimed to assess the molecular allergen sensitisation patterns in the Lithuanian population, particularly focusing on Dermatophagoides pteronyssinus (Der p), and to explore patterns of concomitant reactivity among various allergens to improve HDM allergy diagnostics. Sensitisation patterns to major (Der p 1, Der p 2, and Der p 23) and minor (Der p 5, Der p 7, and Der p 21) Der p allergen components, along with allergen components from other sources, including tropomyosins (Der p 10, Per a 7, Pen m 1, Ani s 3, Blo t 10) and arginine kinases (Pen m 2, Bla g 9, Der p 20), were evaluated using the ALEX² test. A total of 1,520 individuals, both children and adults, with suspected atopic disease were examined.
This study provides valuable insights into HDM allergy sensitization profiles, emphasizing the importance of considering major and minor HDM allergen components for accurate diagnosis and management of HDM‐related allergic diseases. Differences between populations and age‐related factors impact sensitization patterns.
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Sensitization profiles to house dust mite Dermatophagoides pteronyssinus molecular allergens
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