Applications

Comprehensive Solutions for Purification and Analytical Chromatography

Tosoh Bioscience delivers advanced chromatography technologies that cover the entire workflow - from high-resolution analytical characterization to large-scale purification. Explore how our products support critical applications across biopharmaceutical and specialty industries.

Antibodies are the foundation of many therapeutics, including monoclonal antibodies (mAbs), bispecifics, and antibody-drug conjugates.      
 

Purification:

• Multi-step processes for capture, intermediate, and polishing to achieve therapeutic-grade purity.
• Address challenges such as high titers, aggregate removal, and scalability for commercial production.

Analytical Characterization:

• Aggregate detection and charge variant profiling to ensure stability and efficacy.
• Structural analysis for regulatory compliance and comparability studies.

The rapid growth of mRNA vaccines and gene-based therapies demands robust chromatographic solutions.

Purification:

• Scalable workflows for plasmid DNA, mRNA, and oligonucleotides to remove impurities like endotoxins and residual solvents.
• High-resolution separation for large, fragile molecules without compromising integrity.

Analytical Characterization:

• Size and charge analysis for quality control.
• Integrity and purity checks for regulatory submissions.

New sustainable synthetic or natural polymers, polymer-based drug delivery vectors, and common engineering plastics, require thorough characterization to develop well-defined and safe products.      

Analytical Characterization:

• Molecular weight and size distribution analysis using advanced chromatographic separation and detection techniques.  
• Determination of polymer structure, conformation, and composition for in-depth characterization.  

Viral vectors such as Adeno Associated Virus (AAV) and Lentivirus (LV) are essential for delivering genetic material in advanced therapies.      
 

Purification:

• High-efficiency capture and polishing of AAV, lentivirus, and other vectors to maintain infectivity and purity.
• Removal of host cell proteins, DNA, and empty capsids for safety and efficacy.

Analytical Characterization:

• Monitoring impurities, aggregates, and stability throughout development and production.

Peptide-based drugs and vaccines require precise separation strategies.      
 

Purification:

• High-resolution workflows for separating closely related peptide species and removing synthesis by-products.
• Scalable processes for GMP manufacturing.      
   

Analytical Characterization:

• Identity confirmation, impurity profiling, and stability testing using chromatographic methods.      
   

Why Tosoh Bioscience?

End-to-End Expertise      
We provide solutions for both preparative purification and analytical characterization, ensuring seamless integration from early research to full-scale production.

Scalable Innovation      
Our technologies grow with your process—whether you’re developing a new molecule in the lab or manufacturing at commercial scale, Tosoh Bioscience delivers consistent performance and reliability.

Global Support Network      
With technical experts and resources worldwide, we offer guidance, training, and troubleshooting to keep your processes running smoothly.

Regulatory Confidence      
Our products and methods are designed to meet global regulatory standards, helping you achieve compliance and accelerate time-to-market without compromising quality.

Decades of Leadership      
As pioneers in chromatography, we combine proven experience with continuous innovation to support the evolving needs of biopharmaceutical and specialty industries.