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Multi-Column Chromatography

Multi-Column Chromatography

Simpler Than You Think. More Powerful Than You Imagine.

What is Multi-Column Chromatography (MCC)? The Next Step in Efficient Bioprocessing

  • MCC = Multi-Column Chromatography.
  • MCC uses multiple smaller columns instead of one large column.
  • MCC delivers unmatched productivity gains.

Discover More

Octave PRO Front

MCC provides powerful benefits to you

MCC Enhanced Resin Utilization

Enhanced Resin Utilization

Batch: Utilizes a single large column, underutilizing resin capacity as the entire column must accommodate the feed, resulting in significant resin wastage. 

MCC: Employs smaller columns that operate sequentially. Resin capacity is maximized as columns are loaded to their full potential, reducing resin need by up to 90%.

Reduced Buffer Consumption

Batch: Operating a large column through each process phase requires high buffer volumes.

MCC: Optimized resin utilization results in up to 40 % lower buffer demand.

MCC Reduced Buffer Consumption
MCC Faster Processing Times

Faster Processing Times

Batch: Runs with low flow rates and requires sequential steps, leading to idle periods during column re-equilibration.

MCC: Operates columns at high flow rates in parallel, allowing simultaneous loading, separation, elution, and regeneration, drastically reducing processing times.

Increased Productivity

Batch: Limited by the size and capacity of a single column, resulting in a linear relationship between scale and productivity.

MCC: By distributing the workload across multiple smaller columns, MCC achieves a huge increase in productivity, enabling higher throughput without larger equipment investments.

MCC Increased Productivity
MCC Reduced Costs

Reduced Costs

MCC allows considerable cost savings due to lower solvent and resin requirements.

Want to Discuss Your Needs?


At Tosoh, we offer comprehensive support to ensure your success with MCC.    
Our expert team is here to guide you through every step of the process

 

For EMEAFor Americas
Sebastian Thurmann
Jennifer Knister
Sebastian Thürmann  
Commercial Product Manager		Jennifer Knister   
Commercial Product Manager

How Tosoh Supports Your Transition to MCC

We understand the challenges of adopting new technologies and are dedicated to making the transition to MCC as smooth as possible.
 

Our MCC Solutions

Octave™ BIO and PRO Systems: Designed for seamless scalability, these systems support both process development and GMP-compliant manufacturing. Their flexible architecture accommodates up to eight columns.

SkillPak™ Pre-Packed Columns: Pre-packed with TOYOPEARL™ or TSKgel™ resins, these columns are optimized for MCC, providing superior performance for both development and large-scale production.

PROComposer™ Software: Our unified PROComposer method-generating software facilitates method development and quick transition from batch to MCC, ensuring precision and efficiency at every process step.

  • Number 1

    Process Consultation

    Tosoh experts work closely with clients to evaluate workflows and design tailored MCC solutions

  • Number 2

    Training and Workshops

    Hands-on training and educational resources to confidently operate MCC systems

  • Number 3

    Seamless Integration

    Tosoh’s team assists with the transition from batch to MCC, including process optimization and scale-up strategies

  • Number 4

    Installation and IQ/OQ Support

    Guidance on compliance with regulatory standards, including FDA manufacturing practices

Join the Chromatography Intensification Club (CIC) for exclusive training, VIP access, and more benefits!

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