BioProcess International (BPI) East is one of the biopharmaceutical industry's premier conferences, bringing together scientists, engineers, manufacturers, and technology providers to discuss the latest advances in upstream and downstream processing, analytical development, manufacturing strategy, and emerging therapeutic modalities. The event provides a forum for sharing practical solutions that accelerate the development, scale-up, and commercialization of biologics, cell and gene therapies, and other advanced medicines. As a trusted sponsor and chromatography partner, Tosoh Bioscience supports the bioprocessing community with scientifically validated purification technologies that help improve process efficiency, product quality, and manufacturing robustness across a wide range of biologic modalities. Through its portfolio of chromatography resins, columns, and continuous purification solutions, Tosoh Bioscience collaborates with researchers and manufacturers to address critical downstream processing challenges and enable scalable, reliable biomanufacturing workflows. Date: September 22 - 25, 2026 |  |
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| Ashley DePace Territory Manager – New England | Abbie Breton Applications Development Manager | Yuliya McAnany Applications Scientist – Process Media |
Expert Insights from Tosoh Bioscience |
| Presentation |
| When | Friday, September 25, at 12:15 PM |
| Where | Main Stage, Exhibit Hall |
| Presenter(s) | Abbie Breton Applications Development Manager Tosoh Bioscience LLC King of Prussia, PA, USA |
| Topic | Advanced Integration and Process Intensification of a Continuous Downstream Purification Platform for Monoclonal Antibody Production |
Achieving true continuity in downstream processing remains a key challenge for monoclonal antibody (mAb) production. Here, multi-column chromatography (MCC) is advanced beyond continuous capture to enable direct integration of a subsequent chromatographic purification step on a single system. Previous integration of downstream steps has been constrained by equipment and process limitations. The adapted multi-column system used in this work integrates two chromatographic steps in a single 8-column setup, supporting uninterrupted operation and efficient resin use. Using a high alkaline stable, fast kinetic ligand, and high dynamic binding capacity (DBC) Protein A affinity resin, we demonstrate robust mAb capture and subsequent polishing with a highly salt-tolerant cation exchange resin, advancing practical implementation of end-to-end continuous purification. In addition, a low-threshold pH step was applied into this process integration to achieve inline virus inactivation. A high degree of automation has been achieved with this setup, while the footprint has been reduced both by reducing the size of the systems and by saving on cost of buffers, thereby making downstream processing more sustainable. |
Key Highlights Visit Tosoh Bioscience at booth #509 to learn about our chromatography solutions for downstream bioprocessing, including:
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