Sepsis Marker

Sepsis is characterized by a dysregulated immune response to infection resulting in systemic inflammation and organ dysfunction. Presepsin (sCD14-ST), a cleavage product of membrane CD14 released during monocyte–macrophage activation, has emerged as a sensitive biomarker for early sepsis detection. Its plasma concentration rises rapidly in response to bacterial invasion which helps in timely antibiotic administration. Elevated presepsin levels aid in differentiating sepsis from non-infectious SIRS, correlate with disease severity and provide prognostic value.

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Presepsin»